The Monastery of Zoodochos Pigi or Panagia Kalamiotissa is located over the narrow isthmus separating the main island from the Kalamos peninsula.
It is built over the eminent ancient temple of Apollo Aeglitis, which was linked to the asty by the paved Iera Odos (sections of which can still be seen today). Quite high sections of the walls of the temple itself, and its enclosure have been preserved, and incorporated into the enclosure of the modern-day Monastery.
The Monastery has functioned as a pilgrimage since the times of Turkish rule, and is well-known both within and outside Anafi.
The island's most important religious feast takes place there on September 7th-8th.