Thesprotia is one of the regional units of Greece. It is part of the Epirus region. Its capital is the town of Igoumenitsa.
Thesprotia borders Albania to the north, the regional unit of Ioannina to the east and Preveza to the south. The Ionian Sea lies to the west. Much of the regional unit is mountainous. Most farmland is located in the valleys in the central, southern and the western part. Two of Thesprotia's rivers are legendary: the Thyamis and the Acheron of Greek mythology, lined with reedbeds and plane trees.
Thesprotia is traditionally one of the poorest and most remote prefectures of Greece. The main economical activities are agriculture and tourism, with agriculture as historically the main economical activity.
Thesprotia's coastal climate is Mediterranean. Cold winters of a semi-alpine climate dominate the eastern part and higher elevations.