The Chora of Anafi is densely populated and originates from medieval times. It is built amphitheatrically above the port, at an altitude of 260 metres.
With 256 inhabitants today, Chora is distinguished from the capital of other Cycladic islands due to is numerous arched single-room homes, which occupy a large area of the settlement. Narrow cobbled streets criss-cross the village, leading to the Venetian Kastro (fortress), the initial nucleus and heart of the village. Several churches are scattered throughout Chora, including those of Agios Nikolaos , the Kimissi (Assumption), Agios Charalambos, Christos tou Stavrou (Christ of the Cross), Aghioi Anargyroi and Agios Georgios at the top of the Kastro, all with Byzantine or post-Byzantine icons. Findings from ancient Anafi can be viewed in the Archaeological Collection.
Pedestrians are free to wander around, as Chora, being at traditional settlement, is off-limits to vehicles. Various taverns, a rotisserie, a bakery, a grocery store and a bar are available to the local population and visitor. Accommodation is provided by several rooms to let.