Trikala (Greek: Περιφερειακή ενότητα Τρικάλων) is one of the regional units of Greece, forming the northwestern part of the region of Thessaly. Its capital is the town of Trikala. The regional unit includes the town of Kalampaka and the Meteora monastery complex.
Trikala borders the regional units of Karditsa to the south, Arta to the southwest, Ioannina to the west, Grevena to the north and Larissa to the east. The name means 'Three good', good water, good weather and good earth.
The southeastern part belongs to the Thessalian Plain. The forested Pindus mountain range dominates the western part. The northern part of Trikala is also mountainous and made up of forests and barren lands, the ranges here are Chasia and Antichasia. Its major river is the Pineios, flowing to the south and east.
Its climate is mainly of Mediterranean character, with hot summers and cold winters, along with temperate climate conditions by the mountains.