The region of Trikala has been inhabited since prehistoric times. The first indications of permanent settlement have been uncovered in cave of Theopetra, and date back to approx. 49,000 BC. Neolithic settlements dating back to 6,000 BC have been uncovered in Megalo Kefalovriso and other locations.
The ancient city was built at a defensive location in between the local hill and the river Lithaios. The city became and important center in Antiquity and it was considered to be the birthplace and main residence of the Healing God Asclepius. The city exhibited one of the most important and ancient of Asclepius temples asclepieia. The city is mentioned in Homer's Iliad as having participated in the Trojan War with thirty ships under Asclepius' sons Machaon and Podalirius. In the Mycenean period, the city was the capital of a kingdom, and later it constituted the main center of the Thessalian region of Estaiotis, which occupied roughly the territory of the modern Trikala Prefecture.In historical times, the city of Trikke and the surrounding area of the river experienced prosperity. It fell to the Achaemenid Persians in 480 BC, while ten years later it joined the Thessalian monetary union. In 352 BC it was united with the Macedonia of Philip II. The city became a location of hard battles between Macedonia and Rome. While Philip V of Macedon and his son Perseus tried to keep the city, after 168 BC it fell to the Roman Republic.
While the area was considered to be firmly under the rule of the Byzantine Empire, it was invaded nevertheless by a succession of raiders and nomadic tribes. Some of these tribes that raided the area include: Goths (396), Huns (447), Slavs (577), Bulgarians (986-1000), Normans (1082/3), Catalans (1309–1311).
After the dissolution of the Byzantine state by the Fourth Crusade in 1204, Trikala does not appear to have fallen into Frankish hands, but became part of the Despotate of Epirus. Epirote rule lasted until 1259, when the town was taken without resistance by the Empire of Nicaea (after 1261 the renewed Byzantine Empire) following the Battle of Pelagonia. In the early 14th century the town was the capital of a semi-independent domain under the sebastokrator Stephen Gabrielopoulos, which extended across much of western Thessaly and Macedonia. After his death in 1332/3 the city, along with most of Gabrielopoulos' lands, was seized by the Epirote ruler John II Orsini, but he was in turn expelled and the area incorporated into the Byzantine Empire by Andronikos III Palaiologos.
In 1348, Thessaly was conquered by Stephen Dushan and incorporated into the newly established Serbian Empire. The Serbian general Preljub was made the region's governor, and established himself at Trikala. In 1359, Dushan's half-brother Symeon Uroš established his court at Trikala, and in 1366/7 he founded the Meteora monasteries nearby. Symeon was succeeded by his son John Uroš, and he in turn by the local magnates Alexios Angelos Philanthropenos and Manuel Angelos Philanthropenos, who ruled until the Ottoman conquest of Thessaly in 1393/4.
- OTTOMAN AND MODERN PERIODS
The fortunes of the city in the early period of Ottoman rule are unclear: it is reported as being part of a large sanjak under Ahmed, the son of Evrenos Bey, but in the early 15th century it formed part of the domain of Turahan Bey, who brought in Muslim settlers and granted privileges to the local Greek population. Turahan and his son and successor, Ömer Bey, erected many buildings in the city, helping it to "[acquire] the appearance of a typical Ottoman town, with mosques, medreses, a hammam, imaret, khan and karwansaray extending beyond the citadel and the Varoussi (Varosh) quarter which remained Christian" (A. Yerolimpos). As the administrative center of the local province (the Sanjak of Trikala), the city attracted Muslim immigrants and had large Muslim and Jewish communities: in the 1454/5 census, the city had 2,453 inhabitants (251 Muslim families and 9 widows, and 212 Christian families and 73 widows); in 1506, the city numbered 3,100 inhabitants, with 260 Muslim, 310 Christian and 19 Jewish families; in 1520/38, the number had risen to 301 Muslim, 343 Christian, and 181 Jewish families. The city also became an important intellectual center during these years (1543-1854) with the Trikke School (and later Greek School), where famous intellectuals of the time, such as Dionysius the Philosopher, taught.The 17th-century Ottoman traveller Evliya Çelebi reports that the city had 2,300 houses divided into sixteen Muslim and eight Christian quarters (mahalla); eight mosques, of which only the city's main mosque, the Osman Shah Mosque built by Mimar Sinan, survives today; four hammams; six tekkes; and the probably exaggerated number of 1,000 shops, although Evliya curiously does not mention the city's impressive bezesten (covered market) which was demolished in the early 20th century. The city was largely burned down in a great fire in 1749, a destruction repeated by Albanian irregulars following an abortive uprising by the local Christian population during the Orlov Revolt. Despite the destruction, its population seems to have remained the same, ca. 25,000, until the outbreak of the Greek Revolution in 1821.
By 1840, it reportedly had only 10,000 inhabitants, with the last Ottoman census in 1877/8 listing 25,000 inhabitants for the entire sanjak of Trikala. On 23 August 1881 with the Treaty of Constantinople between the Ottoman Empire and the Kingdom of Greece, the city passed in Greek sovereignty, along with the rest of Thessaly. It became occupied again by Ottoman forces briefly during the Greco-Turkish War of 1897.
In the years that followed, Trikala played a fundamental role in the rural workers' mobilizations, in the early 20th century, against the Thessalian landlords. Trikala eventually became the city that the first Agricultural Cooperative of Greece was founded, in 1906. The town lost much of its Ottoman and medieval buildings in the early 20th century, particularly after it was rebuilt to a modern urban plan in the 1930s.
Source: www.wikipedia.org